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Professional Biography

Dr. Das is a seasoned chemist with over a decade of laboratory research experience. He possesses a unique blend of experience in the fields of synthetic organic chemistry, medicinal chemistry and drug discovery. His core expertise includes multi-step organic synthesis, parallel and combinatorial synthesis, homogeneous and asymmetric catalysis, methodology development and synthesis of bio-active small molecules of medicinal importance guided by Structure-Activity Relationship (SAR).

 

Born in Kolkata, India, Dr. Das completed his Bachelor’s degree with honors in Chemistry from the University of Calcutta in 2013. He went on to earn his Master's degree in Chemistry from the Indian Institute of Technology (IIT) Madras in 2015.

 

Dr. Das obtained his Ph.D. in Chemical Sciences from CSIR-National Chemical Laboratory, Pune, India, in 2020 under the guidance of Dr. A. T. Biju. During his Ph.D. (2015-2020), Dr. Das conducted extensive research on organocatalysis and asymmetric synthesis to further understand the underlying mechanisms and potential applications in the synthesis of biologically relevant complex heterocycles and carbocycles.

 

In October 2020, Dr. Das moved to the United States to join Prof. László Kürti's group at Rice University in Houston, Texas, as a Postdoctoral Research Associate. During his stay at Rice University, Dr. Das established several green innovative synthetic platforms for the efficient synthesis of complex heterocycles and functional molecules with medicinal significance.

 

In January 2023, Dr. Das joined the medicinal chemistry team at Calibr, Scripps Research in La Jolla, California, where he led the chemistry efforts in designing and synthesizing preclinical candidates for various drug discovery pipelines targeting diverse diseases areas, including SARS-CoV-2, various CNS disorders, and small molecule vaccine adjuvants.

 

Dr. Das has a proven track record of synthetic chemistry problem-solving, mentoring budding chemists, and working in collaboration with cross-functional teams, CROs and industrial partners. He has authored a dozen articles in reputed international journals, including a book chapter and a review article. He is also a reviewer in several international science journals. In March 2024, Dr. Das joined Oklahoma State University's National Center for Wellness and Recovery (NCWR) as a Senior Research Investigator, with the goal of advancing the development of novel treatments for pain and addiction.

Skills 

  • TECHNICAL SKILLS: mg to 100g scale synthesis, organic chemicals separation and purification, chromatography (normal and reverse phase), distillation, Schlenk techniques, glovebox techniques, microwave reactors, photoreactors, hazardous chemical handling, in-depth SAR(computational/experimental), parallel synthesis, combinatorial synthesis, multi-step synthesis route design and execution, hit-to-lead, lead optimization, molecular docking, interpreting multi-parameter data (potency, activity, PK/PD, ADME etc.).

  • ANALYTICAL TECHNIQUES: FT-NMR (1D, 2D), FT-IR, UV-VIS, GC/MS, LC/MS, HRMS, HPLC, UPLC, scXRD, Biotage® Isolera™, CombiFlash etc.

  • SOFTWARES: ChemDraw®, MestReNova, Live Design, Mercury, Origin, Electronic Lab Notebook: signal, scientific search engines- Reaxys and SciFinder etc.

  • SOFT SKILLS: Synthetic chemistry problem solving, critical thinking, data analysis, writing skills for scientific articles, documents and research grants, communication, teamwork, leadership, creative, organized, experienced in mentoring students and working in collaboration with cross functional teams (e.g., biologists and computational chemists) including industrial partners, managing CROs.

Professional experience 

Sr. Research Investigator (March 2024-Present)

National Center for Wellness & Recovery (NCWR)

Oklahoma State University Center for Health Science, Tulsa, OK, USA.

  • Leading the drug discovery campaign to create innovative treatments for addressing Opioid use disorders.

Postdoctoral Associate (January 2023-March 2024)

Calibr, Scripps Research, La Jolla, CA, USA [PI: Arnab Chatterjee]

  • Led chemistry efforts in designing and synthesizing preclinical candidates for the treatment of 2019 Novel Coronavirus (SARS-CoV-2), targeting MPro of the virus.

  • Streamlined SAR-driven synthesis of pan-antiviral drug candidates.

  • Strategized and executed SAR-driven synthesis of small molecule vaccine adjuvants.

  • Actively contributed to the development of novel therapies for various CNS disorders.

 

Postdoctoral Research Associate (October 2020-January 2023)

Rice University, Houston, TX, USA [PI: Prof. László Kürti]

  • Pioneered innovative synthetic methods, establishing robust platforms for the efficient synthesis of complex heterocycles and functional molecules with medicinal significance.

  • Designed and synthesized cutting-edge organocatalysts for the enantioselective aziridination reactions in collaboration with Merck & Co.

 

PhD Research Scholar (July 2015-June 2020)

CSIR-National Chemical Laboratory, Pune, India. [PI:Prof. A. T. Biju]

  • Conducted extensive research on organocatalysis and asymmetric synthesis to further understand the underlying mechanisms and potential applications, resulting in a series of published articles in top-tier scientific journals including a book chapter and a review article.

  • Pioneered the novel N-heterocyclic carbene catalyzed imine umpolung strategy, establishing a versatile synthetic platform for diverse nitrogen heterocycles.

Education

  1. Ph.D. in Chemical Sciences, Academy of Scientific and Innovative Research (AcSIR), Research Carried out at CSIR-National Chemical Laboratory, Pune, India. [PhD mentor:  Prof. A. T. Biju] (2015-2020)

  2. M.Sc. in Chemistry, Indian Institute of Technology (IIT) Madras, India. (2013-2015)

  3. B.Sc. in Chemistry (Hons.), University of Calcutta, Kolkata, India. (2010-2013)

 Scholarships and Awards

1.  Junior Research Fellowship (JRF) by the Council of Scientific and Industrial Research (CSIR), New Delhi, India (Duration: 2015-2020) (All India Rank 96).

2.  Research Fellowship for qualifying Graduate Aptitude Test in Engineering (GATE) conducted by IIT Kanpur (2015).

3.  INSPIRE Scholarship by Department of Science and Technology (DST), New Delhi, India (Duration: 2010-2015).

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